Olink Target 48 Cytokine は、わずか 1μL の血清・血漿サンプルから一度に 45因子 のサイトカイン類を絶対定量します。
ここでは、さまざまな研究分野において、 Olink Target 48 Cytokine が活用されている事例を紹介いたします。
免疫学/炎症学
食物アレルギー、小児
Crestani E, Benamar M, Phipatanakul W, et al. Age-specific Metabolomic profiles in children with food allergy. (2024) Clinical Immunology,
DOI: 10.1016/j.clim.2024.109928.
口腔、炎症、バイオマーカー
Virdee SS, Bashir N, Krstic M, et al. Periradicular tissue fluid-derived biomarkers for apical periodontitis: an in vitro methodological and in vivo cross-sectional study. (2023) International Endodontic Journal,
食道、炎症
Kleuskens MTA, Bek MK, Al Halabi Y, et al. Mast cells disrupt the function of the esophageal epithelial barrier. (2023) Mucosal immunology,
DOI: 10.1016/j.mucimm.2023.06.001
腸管、遺伝子変異
Rodari MM, Cazals-Hatem D, Uzzan M, et al. Insights into the expanding intestinal phenotypic spectrum of SOCS1 haploinsufficiency and therapeutic options. (2023) Journal of Clinical Immunology,
DOI: 10.1007/s10875-023-01495-7
喘息、感染
Radzikowska U, Eljaszewicz A, Tan G, et al. Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19. (2023) Nature Communications,
DOI: 10.1038/s41467-023-37470-4
COVID-19、mRNAワクチン、心血管疾患
Ong EZ, Koh CWT, Tng DJH, et al. RNase2 is a possible trigger of acute-on-chronic inflammation leading to mRNA vaccine-associated cardiac complication. (2023) Med,
DOI: 10.1016/j.medj.2023.04.001
薬理学、グルココルチコイド
Othonos N, Pofi R, Arvaniti A, et al. 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial. (2023) Nature Communications,
DOI: 10.1038/s41467-023-36541-w
症例報告、遺伝子変異、小児
Michniacki TF, Walkovich K, DeMeyer L, et al. SOCS1 Haploinsufficiency Presenting as Severe Enthesitis, Bone Marrow Hypocellularity, and Refractory Thrombocytopenia in a Pediatric Patient with Subsequent Response to JAK Inhibition. (2022) Journal of Clinical Immunology,
神経学
スポーツ関連脳震盪、免疫
Di Battista AP, Rhind SG, Shiu M, et al. Whole blood stimulation provides preliminary evidence of altered immune function following SRC. (2024) BMC Immunology,
DOI: 10.1186/s12865-023-00595-8
アルツハイマー、臨床試験
Faridar A, Eid AM, Thome AD, et al. A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease. (2023) Translational Neurodegeneration,
DOI: 10.1186/s40035-023-00387-5
多発性硬化症、免疫吸着療法
Pfeuffer S, Rolfes L, Wirth T, et al. Immunoadsorption versus double-dose methylprednisolone in refractory multiple sclerosis relapses. (2022) Journal of Neuroinflammation,
DOI: 10.1186/s12974-022-02583-y
筋萎縮性側索硬化症、制御性 T リンパ球
Thonhoff JR, Berry JD, Macklin EA, et al. Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis. (2022) Neurology, Neuroimmunology and Neuroinflammation,
DOI: 10.1212/NXI.0000000000200019
老化
術後せん妄、老化、バイオマーカー
Lozano-Vicario L, Muñoz-Vázquez ÁJ, Ramírez-Vélez R, et al. Association of postoperative delirium with serum and cerebrospinal fluid proteomic profiles: a prospective cohort study in older hip fracture patients. (2024) GeroScience,
DOI: 10.1007/s11357-024-01071-w
高齢者、骨粗鬆症、骨折、バイオマーカー
Cedeno-Veloz BA, Lozano-Vicario L, Zambom-Ferraresi F, et al. Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults. (2023) Immunity & Ageing,
DOI: 10.1186/s12979-023-00379-z
高齢者、骨折、バイオマーカー
Cedeno-Veloz B, Lozano-Vicario L, Rodríguez-García A, et al. Serum biomarkers related to frailty predict negative outcomes in older adults with hip fracture. (2023) Journal of Endocrinological Investigation,
DOI: 10.1007/s40618-023-02181-6
栄養学
栄養、免疫
Kawano T, Miura A, Naito J, et al. High-parameter immune profiling and subjective health assessment of the immunomodulatory effects of paramylon-rich Euglena gracilis EOD-1: A randomized, double-blind, placebo-controlled, parallel-group study. (2023) Journal of Functional Foods,
感染症(COVID-19)
COVID-19後遺症、マルチオミクス
Mahdi A, Zhao A, Fredengren E, et al. Dysregulations in hemostasis, metabolism, immune response, and angiogenesis in post-acute COVID-19 syndrome with and without postural orthostatic tachycardia syndrome: a multi-omic profiling study. (2023) Scientific Reports,
DOI: 10.1038/s41598-023-47539-1
COVID-19後遺症、炎症
Allan-Blitz LT, Goodrich J, Hu H, et al. Altered Tumor Necrosis Factor Response in Neurologic Postacute SARS-CoV-2 Syndrome. (2023) Journal of Interferon & Cytokine Research,
DOI: 10.1089/jir.2023.0051
COVID-19、バイオマーカー
Rosendal E, Mihai IS, Becker M, et al. Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections. (2022) mBio,
DOI: 10.1128/mbio.00892-22